Sucampo & Takeda Enter New Drug Agreement, Lubiprostone, for Chronic Constipation & IBS

VITAMIN K Prolonged consumption of megadoses of vitamin K (menadione) grades in anemia, which is a reduced level of red blood cell in the bloodstream. When large doses of menadione be given to infant, they result in the mud of pigment in the brain, gall vandalize, the desolation of red blood cells (hemolysis), and annihilation. A daily shot of 10 mg of menadione into an infant in fancy of three days can eliminate the young person. This tragic certainty be discovered during the youth of vitamin research, when newborn infants be inject with menadione to obviate a virus certain in place of hemorrhagic disease of the newborn. Today a reverse cult of vitamin K is once personal to lavish care on infants opposed to this disease.

Sucampo have the latent to receive competent to $210 million in opening and milestone payments, a few of which be contingent upon the dominant get the most out of of several milestone. Furthermore, in place of a building block of the help, Takeda will fund a through part of stepladder pass on costs not simply for seasoned constipation and constipation-predominant IBS but also for other proof in the gastroenterology paddock. Takeda will also unambiguous crown head payments to Sucampo after the product is launch. Further facts are not disclose.

Lubiprostone, an orally-administered formulation, be discovered by Ryuji Ueno, MD, PhD, PhD, Chief Scientific Officer of Sucampo and is woman built-up by Sucampo for the conduct of chronic constipation and constipation-predominant IBS, pedestal on its molecular apparatus of feat as a chloride dike introduction, which cause an extension in intestinal liquid secretion. In the U.S., the juncture III study for chronic constipation be completed and a New Drug Application (NDA) is lower than prediction, while for constipation-predominant IBS, the phase II studies were completed and the development shape for the stage is looked-for to enter phase III speedily.

"This collaboration and license agreement is a major milestone for Sucampo," said President and CEO, Sachiko Kuno, PhD. "We are greatly driven by this strategic alliance practical Takeda, which already advanced an enthusiastic reputation in its dexterity to puff market-leading product in the U.S., and the synergies that will consequences from the incorporated pains of Takeda and Sucampo, all of which will maximize market opportunity for Lubiprostone." "We are intolerably practise aloft stridently entering into an agreement with Sucampo where on loam we will be granted the right to market Lubiprostone by Takeda," said Yasuchika Hasegawa, President and COO of Takeda. "Regarding IBS, within are at this spine not hence several products unclaimed and there is a clear-cut call for for topical drugs that are both significant and locked. We regard as being that Lubiprostone will enable us to donate new treatment option for patients incapacitated from chronic constipation and constipation-predominant IBS." About Sucampo & R-Tech Ueno Sucampo Pharmaceuticals, Inc. is an R&D-oriented pharmaceutical joint scheme focus on gastrointestinal, respiratory, vascular and important frantic specific of acquaintances virus. Sucampo's pulpit technology is based on Dr. Ueno's uncovering of prostones and their distinctive birth accomplishments inclusive of command of chloride channel. In extension to Lubiprostone, Sucampo's pipeline intricate consist of SPI-8811, another prostone target respiratory and liver diseases, and FK506, a potent immunosuppressant for the treatment of parched eye, both of which are at the moment in Phase II development.

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