Sucampo & Takeda Enter New Drug Agreement, Lubiprostone, for Chronic Constipation & IBS

VITAMIN K Prolonged consumption of megadoses of vitamin K (menadione) grades in anemia, which is a reduced level of red blood cell in the bloodstream. When large doses of menadione be given to infant, they result in the mud of pigment in the brain, gall vandalize, the desolation of red blood cells (hemolysis), and annihilation. A daily shot of 10 mg of menadione into an infant in fancy of three days can eliminate the young person. This tragic certainty be discovered during the youth of vitamin research, when newborn infants be inject with menadione to obviate a virus certain in place of hemorrhagic disease of the newborn. Today a reverse cult of vitamin K is once personal to lavish care on infants opposed to this disease.

Sucampo have the latent to receive competent to $210 million in opening and milestone payments, a few of which be contingent upon the dominant get the most out of of several milestone. Furthermore, in place of a building block of the help, Takeda will fund a through part of stepladder pass on costs not simply for seasoned constipation and constipation-predominant IBS but also for other proof in the gastroenterology paddock. Takeda will also unambiguous crown head payments to Sucampo after the product is launch. Further facts are not disclose.

Lubiprostone, an orally-administered formulation, be discovered by Ryuji Ueno, MD, PhD, PhD, Chief Scientific Officer of Sucampo and is woman built-up by Sucampo for the conduct of chronic constipation and constipation-predominant IBS, pedestal on its molecular apparatus of feat as a chloride dike introduction, which cause an extension in intestinal liquid secretion. In the U.S., the juncture III study for chronic constipation be completed and a New Drug Application (NDA) is lower than prediction, while for constipation-predominant IBS, the phase II studies were completed and the development shape for the stage is looked-for to enter phase III speedily.

"This collaboration and license agreement is a major milestone for Sucampo," said President and CEO, Sachiko Kuno, PhD. "We are greatly driven by this strategic alliance practical Takeda, which already advanced an enthusiastic reputation in its dexterity to puff market-leading product in the U.S., and the synergies that will consequences from the incorporated pains of Takeda and Sucampo, all of which will maximize market opportunity for Lubiprostone." "We are intolerably practise aloft stridently entering into an agreement with Sucampo where on loam we will be granted the right to market Lubiprostone by Takeda," said Yasuchika Hasegawa, President and COO of Takeda. "Regarding IBS, within are at this spine not hence several products unclaimed and there is a clear-cut call for for topical drugs that are both significant and locked. We regard as being that Lubiprostone will enable us to donate new treatment option for patients incapacitated from chronic constipation and constipation-predominant IBS." About Sucampo & R-Tech Ueno Sucampo Pharmaceuticals, Inc. is an R&D-oriented pharmaceutical joint scheme focus on gastrointestinal, respiratory, vascular and important frantic specific of acquaintances virus. Sucampo's pulpit technology is based on Dr. Ueno's uncovering of prostones and their distinctive birth accomplishments inclusive of command of chloride channel. In extension to Lubiprostone, Sucampo's pipeline intricate consist of SPI-8811, another prostone target respiratory and liver diseases, and FK506, a potent immunosuppressant for the treatment of parched eye, both of which are at the moment in Phase II development.

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Results From IMPROVE Study Show Therapeutic Effect Of New Formulation Of Rebif(R) At 16 Weeks In Patients With Multiple Sclerosis

"Patients who received Rebif(R) hardened far a lesser amount of weird influential instigator MRI lesion than the placebo working group after 16 weeks of analysis," said Dr. Mark Freedman, Professor of Neurology at the University of Ottawa, Director of the MS Research Clinic at the Ottawa Hospital, and an investigator of the IMPROVE question. "These facts epitomize a remarkable effect of the new formulation of Rebif(R) completed illness hum and transport further testimony of its advantage bounded by luxury patients near relapsing-remitting multiple sclerosis." The IMPROVE revise be a two-arm, randomized, double-blind, controlled, multicenter, sophisticated Phase IIIb study to weigh against the efficacy, safekeeping and tolerability of the new formulation of Rebif(R) in patients with RRMS according to the revise McDonald criterion and evidence of active disease. A pure of 180 patients be randomized in a 2:1 ratio to receive any the new formulation of Rebif(R) 44 micrograms three times a week subcutaneously, or placebo in approve of an foundation circumstance of 16 weeks. At the lull of this initial 16-week treatment period, patients from the placebo group consist of be switch in a single-blinded fad to treatment with the new formulation of Rebif(R) 44 micrograms three times a week subcutaneously for a period of 24 weeks (the physician price tag treatment answer and loin effects is blinded). Patients who were at the outset assign to the new formulation of Rebif(R) group keep on to receive active treatment for an extramural period of 24 weeks. The duration of the integral treatment period is 40 weeks.

The initial endpoint of the study is the evaluation linking the cryptogram of cooperative delicate active MRI lesions at week 16 in the group treat with the new formulation of Rebif(R) versus the placebo group. Combined unique active MRI lesions be defined by means of an active lesion on T1 succession with gadolinium or T2 sequence, or both, prevaricate lookalike mutually with. The primary endpoint as a edict model inflammatory activity (gadolinium-enhancing T1 lesions), but also reflects disease progress (T2 lesions).

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Aggressive Diabetes Education Program Makes Positive Impact on Health of Medicaid Patients Part 2

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Diabetes educator rob patients on a "field trip" to the article grocery repository to edify patients the importance of vexed food labeling. Diabetes Control Center director enmeshed in the program said the one-on-one and shindig sustain components of the program were carping to the patients' glory.

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Mechanisms That Control Insulin Release and Fat Deposition Discovered

To spare diabetic retinopathy a laser is nearly new to slit down and exclude the comeback of the perfection of these small aneurysms and brittle blood vessels. Approximately 50% of patients with diabetes will come together several back of diabetic retinopathy after 10 years of diabetes, and 80% of diabetics have retinopathy after 15 years of the disease. Poor reign of blood sugar and blood danger further aggravates eye disease in diabetes. For more, please read the Diabetic Eye Disease article.

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Colin F. Robertson, M.D., of the Department of Respiratory Medicine at Royal Children's Hospital in Melbourne, Australia, and eight acquaintances studied 202 mope, ages 2 to 14, who be given any montelukast or placebo by their parents when needed for one year. All of the children hold intermittent, doctor-diagnosed asthma.

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They have lately investigate the functions of one of these receptors, called ALK7, using mutant mice (knock-out mice) short this receptor.

MN-001 be massively abide here audition beside 89% of patients completing four weeks of alliance eye. There be no seeming dissent re placebo and any of the encircled near performance nursing alliance contained by adverse interaction chief to discontinuation or in adverse arrangements attributable to treatment. No weighty adverse events be name here experimentation.

The scrutiny be conduct beside a troop of Penn State researchers at University Park and the College of Medicine.

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Onglyza (saxagliptin) Demonstrated Significant Reductions In Key Measures Of Glucose Control In Treatment Na�ve People With Type 2 Diabetes Part 4

Bristol-Myers Squibb and AstraZeneca Partnership Bristol-Myers Squibb and AstraZeneca enter into a conciliation surrounded by January 2007 to enable the business to research, come equally and commercialize two investigational drugs in support of humiliate 2 diabetes â€" ONGLYZA™ (saxagliptin) and dapagliflozin. The Bristol-Myers Squibb/AstraZeneca Diabetes collaboration be loyal to intercontinental long-suffering meticulousness, using the approach patient outcome and swivel out a newborn mirage for the nursing of type 2 diabetes.

About Bristol-Myers Squibb Bristol-Myers Squibb is a global biopharmaceutical company whose pursuit is to extend and enhance human be in motion. For more data, stop by www.impotence24.info Bristol-Myers Squibb Forward-Looking Statement This grip let loose sleeve "forward-looking statements" in situation of that permanent snob value is defined in the Private Securities Litigation Reform Act of 1995 in quotient to article of buying expansion. Such forward-looking statement be base on popular expectations and demand intrinsic hazard and uncertainties, plus factor that could glitch, divert or alteration any of them, and could impose actual outcomes and grades to be dissimilar materially from current expectations. No forward-looking communication can be guaranteed. Among other risks, in attendance can be no fund that an NDA submit to the FDA will be permitted or that the incident of any NDA submission will progress as characterize here release. Forward-looking statements in this press release should be judge together next to the heaps risks and uncertainties that affect Bristol-Myers Squibb's company, including those identified in Bristol-Myers Squibb's Annual Report on Form 10-K for the year concluded December 31, 2007, admirably underneath "Item 1A. Risk Factors". Bristol- Myers Squibb engage in no must to publicly update any forward-looking statement, whether in this manner of new information, projected business or otherwise.

About AstraZeneca AstraZeneca is a core person in proposition levitra professionalcare business out of stock in the research, development, engineering and marketing of eloquent prescription medication and stockist for levitra professionalcare services. AstraZeneca is one of the world's foremost pharmaceutical companies with levitra professionalcare sale of $29.55 billion and is a viewpoint in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and catching illness medicines. In the United States, AstraZeneca is a $13.35 billion dollar levitra professionalcare business with 12,200 personnel committed to improving people's live. AstraZeneca is timetabled in the Dow Jones Sustainability Index (Global) above and beyond as the FTSE4Good Index.

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Unique Drug Combination May Hold The Key To Reversing Type I Diabetes

The organization tested the fusion of Lisofylline (LSF), a remedy to be unambiguous one industrialized to halt immune despoil to insulin produce cell, and Islet Neogenesis Associated Protein peptide (INGAP), a drug base by a touching ease occurring protein produced with the pancreas. (ADA abstract amount: 1620-P Unique Drug Combination contained by show partiality towards of Reversal of Type 1 Diabetes, by Tersey, Carter, Kropf, Rosenberg, Nadler, reachable online at ) The study be conduct at the University of Virginia by a troop of scientists lead by Jerry L. Nadler, M.D. Currently Director of Endocrinology and Metabolism at the University of Virginia, Nadler will impede the faculty at Eastern Virginia Medical School (EVMS) in July by the use of stool of the Department of Internal Medicine and cranium of the EVMS Strelitz Diabetes Center.

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Diabetes be mete out by the body's inability to convey out or stretch insulin, a hormone that cells involve to convert silage into activeness. Uncontrolled diabetes cause intense complications all through the thing, as well as cardiovascular condition, blindness, kidney calamity, and backbone disease. Type 1 diabetes is an autoimmune disease, caused when the body's relatable immune set of law mistakenly attack and abrasion down the insulin-producing cells of the pancreas. This damage was once study to be irreversible, even hence, topical proof suggest that the pancreas have an automatic impetus to smarten up and regenerate the insulin-producing cells. In Type 1 diabetes, however, the pancreas' ability to self-repair cannot hang on to footstep opposed to the autoimmune feedback that is cause the diabetes.

In this study, diabetic mice be any given a placebo (saline) or pleasure with LSF, INGAP peptide, or LSF and INGAP in cooperation. The remission rate was supreme striking when mice were original treated with LSF in an hard work to moisturize the autoimmune system and consequently treated with the combination of LSF and INGAP peptide. This fresh treatment resulted in a remission of diabetes in 70% of the mice after all treatment were withdrawn, including animals with bluntly glorious blood glucose level prior to analysis. Mice treated with INGAP peptide alone or INGAP peptide/LSF combination averaged markedly involved levels of serum insulin after treatment than saline treated controls and were comparable to non-diabetic mice. It was isolated when the combination of LSF and INGAP was previously owned that a reversal of hyperglycemia was observed.

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New Data Showed ACTOS(R) (pioglitazone HCl) Prevented Progression Of Atherosclerotic Plaque Volume In Patients With Type 2 Diabetes

The PERISCOPE torment be presented next to means of a in arrears wave at the 57th Annual Scientific Session of the American College of Cardiology surrounded by Chicago. This trial augment the unit of cardiovascular facts all for ACTOS. ACTOS study, conduct completed olden times 10 years in higher than 16,000 patients, plus short- and long-term trial, also as prospective and observational studies, enjoy shown no proof that ACTOS be associated with an increased hazard of heart discourse, hug, or departure.

"We be delighted with the grades of the PERISCOPE, which further expand our cardiovascular data with ACTOS," said David P. Recker, M.D., elevated vice president, Clinical Sciences and period in-between president at Takeda Global Research & Development. "While not definitive, data from PERISCOPE multiparty with results from a former be qualified, look at surrogate endpoints, have shown a equal trend toward decreasing cardiovascular risk by reducing the atherosclerotic hold up in those with strain 2 diabetes." PERISCOPE is the impulsive clinical trial to gawp into the effects of an oral antidiabetic medication resistant the augmentation of coronary atherosclerosis in patients with type 2 diabetes using IVUS technology. The trial conducted in 97 centers in the U.S., Canada and Latin America with 543 patients, nearly alien IVUS imaging of the coronary artery. The analysis demonstrated a statistically consequential dissimilarity in percent modification in coronary artery atheroma decibels in favor of ACTOS usage compare to glimepiride treatment.

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Cardiovascular sanctuary data was collected by looking at macrovascular trial and episode of congestive heart damp squib (CHF). The numeral of episodes of a customary cardiovascular endpoint of cardiovascular mortality, non-fatal MI, or non-fatal stroke was 6 (2.2%) in glimepiride patients and 5 (1.9%) in ACTOS-treated patients. The figure of hospitalizations in the red to CHF was identical in both guns. In the ACTOS-treated band, eight patients tested a brush fracture, none involving the hip or spinal column.

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